Wash Away Allergens Dust mites tend to thrive in bedding, pillows, and throw rugs. And since we spend so much of our time in the bedroom, it’s especially important to reduce allergens there. At least once a week, wash pillowcases, sheets, and blankets in very hot water — at least 130 degrees — and dry them in a hot dryer to kill dust mites. Also, encase mattresses and non-washable pillows, comforters, and other bedding in allergen-proof covers.