And when Molly tried to imply he only cared about John's opinions/concerns he quickly let her know she always counted too. So all we've really learned from this is, when pressed, he will be considerate of peoples emotions.
The thing that most american sherlockians don't realize is, in England "trousers" are "pants", and "pants" are "underwear". John isn't talking about Sherlock's pants he's talking about his underwear. One of my favorite scenes.