The mayapple had an important place in the primitive medicine of the Native Americans & early settlers. The plant was used to treat certain warts & the roots were used to treat jaundice, fever, liver ailments, & syphilis. The mayapple is still used today in folk medicine in some areas of the Appalachian Mountains. A tea made from the roots is used to treat constipation. Source: USDA Forest Service Publication, October 6, 1973.